TMC435 (HCV protease)

Therapy Area
Treatment of hepatitis C virus (HCV) infection.

Phase
Phase I studies completed and reported. Phase IIa studies in patients are ongoing. Phase IIb studies to be initiated.
Competitive Edge
Novel HCV NS3/4A protease inhibitor with excellent antiviral activity in HCV infected patients. PK profile supporting a once-daily dosing.
Project data
  • Collaboration with Tibotec since 2004
  • Phase IIa studies ongoing
  • Excellent antiviral activity in HCV infected patients
  • PK profile supporting a once-daily dosing
  • Several series of potent inhibitors have been developed that provide backups

Last Modified: 29/04/2009